Product ID:ACCESS TROPONIN I, 2 X 50 DETERMINATIONS, 33320
MSDS Date:11/18/1997
FSC:NIIN:Submitter:N EN
Status Code:A
MSDS Number: CKMRJ

BECKMAN INSTRUMENTS, INC.

1000 LAKE HAZELTINE DRIVE
CHASKA, MN 55318-1084
US

Emergency Phone: 800-854-3633

Info Phone: (612) 448-4848

Cage: TO606

SANOFI DIAGNOSTICS PASTEUR

CHASKA, MN 55318 US

Telephone: 800-666-7111; 612-448-4848

Cage: 0TEN9

PROCLIN 300. 2-CHLORO-2 METHYL-4-ISOTHIAZOLIN-3-ONE (MFR

PROCLIN 300. 2-METHYL-4-ISOTHIAZOLIN-3-ONE (MFR CAS #

PARAMAGNETIC PARTICLES. PMP

ETHYLENE DIAMINE TETRAACETIC ACID. C10H16N2O8 EDTA

CAS: 60-00-4

RTECS: AH4025000

EPA Report Quantity: 5000 LBS

DOT Report Quantity: 5000 LBS

ALKALINE PHOSPHATASE. (MFR CAS # 9001-78-9)

SODIUM AZIDE. NAN3

CAS: 26628-22-8

RTECS: VY8050000

EPA Report Quantity: 1000 LBS

DOT Report Quantity: 1000 LBS

TRIS HYDROXYMETHYL AMINOMETHANE. (ACID/BASE) (MFR CAS

CAS: 77-86-1

RTECS: TY2900000

ANIMAL SERUM. (MURINE)

ANIMAL ASCITES. (MURINE)

GLYCEROL. C3H8O3

CAS: 56-81-5

RTECS: MA8050000

OSHA PEL 15 MG/M3

ACGIH TLV: 10 MG/M3

BOVINE SERUM ALBUMIN. (BSA)

CAS: 9048-46-8

SURFACTANT TWEEN 20. (MFR CAS #9005-64-5)

MISC. INORGANIC SALTS. (I.E. NACL, MGCL2 AND ZNCL2)

WATER. H2O

CAS: 7732-18-5

RTECS: ZC0110000

SUCCINIC ACID. (BUTANEDIOIC ACID) C4H6O4

CAS: 110-15-6

RTECS: WM4900000

SODIUM HYDROXIDE. NAOH

CAS: 1310-73-2

RTECS: WB4900000

OSHA PEL 2 MG/M3

EPA Report Quantity: 1000 LBS

DOT Report Quantity: 1000 LBS

LD50 LC50 Mixture:LD50 (RAT ORAL): 27 MG/KG (SODIUM AZIDE)
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:[PROCLIN 300]-MICROBIOCIDE
PRESERVATIVE THAT IN ITS CONC FORM IS A TOXIC CORROSIVE. AT THE
CONC OF THIS PRODUCT, IT IS NOT CORROSIVE, BUT IS AN EYE, SKIN &
UPPER RESP IRRIT. DELAYED ALLERGIC CONTACT D ERMATITIS HAS BEEN
OBSERVED IN HUMANS. [PARAMAGNETIC PARTICLES]- SMALL MAGNETIC
PARTICLES WITH AN OUTER COATING OF PLASTIC. THE MAGNETIC PARTICLE
IS IRON BASED; COATING IS LATEX BASED. PARTICLES ARE C ONSIDERED
NORMAL MATLS BUT TAKE ON THE HAZARDS OF ANY PROTEINS BOUND TO THEIR
SURFACE (OTHER INFORMATION)
Effects of Overexposure:SYMPTOMS OF OVEREXPOSURE MAY INCLUDE: HEADACHE,
CONGESTION & EYE IRRITATION. SKIN CONTACT MAY RESULT IN DERMATITIS.
OVEREXPOSURE TO AZIDE MAY CAUSE HEADACHES, DIZZINESS AND FAINTING.

First Aid:EYE CONTACT: FLUSH W/COPIOUS AMOUNTS OF WATER FOR AT LEAST 15
MIN. ENSURE ADEQUATE FLUSHING BY SEPARATING EYELIDS W/FINGERS WHILE
FLUSHING WITH WATER. SKIN CONTACT: REMOVE CONTAM CLOTHING. WASH &
RINS E AFFECTED AREA(S) THOROUGHLY W/SOAP & H2*0 AND RINSE W/H2*O.
MAYCAUSE ALLERGIC SKIN REACTIONS. SWALLOWING: WASH OUT MOUTH
W/WATER PROVIDED PERSON IS CONCIOUS. INDUCE VOMITING. CALL AN MD OR
LOCAL POI SON CONTROL CENTER. INHALATION: REMOVE FROM EXPOSURE AREA
TO FRESH AIR.

Extinguishing Media:WATER, CO*2, DRY CHEMICAL OR ALCOHOL FOAM.
Fire Fighting Procedures:SELF-CONTAINED BREATHING APPARATUS &
PROTECTIVE CLOTHING SHOULD BE WORN.
Unusual Fire/Explosion Hazard:COMBUSTION PRODUCTS: PRINCIPALLY CARBON,
NITROGEN & SULFUR OXIDES. NOT FLAMMABLE (EXCEPT PACKAGING
MATERIALS).

Spill Release Procedures:CLEANUP WITH ABSORBENT MATERIAL & APPROPRIATE
DISINFECTANT. ABSORB & PLACE IN SUITABLE WASTE CONTAINER. USE
UNIVERSAL PRECAUTIONS & GOOD CLINICAL LAB PRACTICES. AVOID DIRECT
CONTACT W/MATL BY WEARIN G APPROPRIATE PERSONAL PROTECTIVE
EQUIPMENT SUCH AS GLOVES, FACESHIELD, LAB COAT, ETC.

Handling and Storage Precautions:HANDLING: FOLLOW PROPER LAB SAFETY
GUIDELINES FOR CHEMICALS & BIOLOGICALS. WEAR GLOVES TO PREVENT SKIN
CONTACT. AVOID SPLASHING OR GENERATION OF AEROSOLS. (OTHER
PRECAUTIONS)
Other Precautions:(HANDLING/STORAGE CONT'D) WEAR APPROPRIATE PERSONAL
PROTECTIVE EQUIPMENT SUCH AS FACE SHIELD, GLOVES, LAB COAT, ETC.
CONSULT WITH YOUR SAFETY & ENVIRONMENTAL HEALTH OFFICER. HANDLE IAW
LOCAL, STATE & FEDERAL REGULATIONS. STORING: STORE AT 2C TO 10C.
AVOID FREEZING REAGENTS.

Respiratory Protection:A NIOSH-APPROVED RESPIRATOR APPROPRIATE FOR THE
EXPOSURE OF CONCERN .
Ventilation:NORMAL LAB VENTILATION IS ADEQUATE UNLESS AEROSOLS ARE
GENERATED-IF SO, CONSULT WITH YOUR SAFETY AND ENVRIONMENTAL HEALTH
OFFICER.
Protective Gloves:APPROPRIATE TO PREVENT SKIN CONTACT. WASH HANDS
THOROUGHLY AFTER REMOVING GLOVE
Eye Protection:ANSI-APPROVED CHEMICAL SAFETY GOGGLES & FULL FACESHIELD
.
Other Protective Equipment:EYEWASH & DELUGE SHOWER MEETING ANSI DESIGN
CRITERIA . PROTECTIVE CLOTHING: LAB COAT OR GOWN TO PREVENT SKIN
CONTACT.
Supplemental Safety and Health
REFER TO ASSAY MANUAL FOR PRODUCT INSERT FOR ADDITIONAL PRODUCT
INFORMATION. REAGENTS ARE A MIXTURE OF INGREDIENTS. REFER TO
CHEMICAL SPECIFIC MSDS FOR ADDITIONAL DATA.

pH:SEE FED REGS.
Solubility in Water:YES
Appearance and Odor:SEE FEDERAL REGULATORY BLOCK

Stability Indicator/Materials to Avoid:YES
SODIUM AZIDE MAY REACT WITH LEAD & COPPER PLUMBING TO FORM HIGHLY
EXPLOSIVE METAL AZIDES.

Waste Disposal Methods:DISPOSE OF MATERIAL IAW LOCAL, STATE & FEDERAL
REGULATIONS. CONTACT YOUR SAFETY & ENVIRONMENTAL HEALTH OFFICER FOR
DISPOSAL PROCEDURES. ON DISPOSAL, FLUSH WITH A LARGE VOLUME OF
WATER TO PREVENT AZIDE BUILDUP.

Toxicological Information:PROCLIN 300: LD50 (RAT ORAL): 500 MG/KG &
LD50 (RABBIT DERMAL): 500 MG/KG. SODIUM AZIDE: LD50 (RAT ORAL): 27
MG/KG.

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.

Transport Information:(HAZARDS-CONTINUED FROM STATE REGULATORY) MILD
MUC MEMB & SKIN IRRITANT. NOT HAZARDOUS AT KIT CONCENTRATION.
[SODIUM HYDROXIDE]- TOXIC CORROSIVE. HARMFUL IF SWALLOWED, INHALED
OR ABSORBED THRU SKIN. D ESTRUCTIVE TO TISSUE. CAUSTIC CAPABLE OF
CAUSING SEVERE BURNS TO MUC MEMBS, UPPER RESP TRACT, EYES & SKIN.
[GLYCEROL] CAUSES EYE IRRITATION. CAN CAUSE SKIN IRRITATION.

Federal Regulatory Information:(CONT'D FROM PH FIELD OF
'PHYSICAL/CHEMICAL' BLOCK) ALL CHEMICAL REAGENTS ARE BETWEEN PH 5 &
9 EXCEPT: *REAGENT WELL B --- BETWEEN PH 11 AND 13. *REAGENT WELL
C --- BETWEEN PH 1 AND 3. (CONT'D FROM ' APPEARANCE' FIELD OF
'PHYSICAL/CHEMICAL' BLOCK) REAGENT PACK - TRANSLUCENT SOLID
CONTAINER WITH LIQUID IN ALL FIVE WELLS. ODOR: NONE.
State Regulatory Information:(HAZARDS-CONTINUED FROM OTHER INFO) [TRIS
HYDROXYMETHYL AMINOMETHANE]- IRRITATING TO MUC MEMB & UPPER RESP
TRACT. [ANIMAL SERUM]&[ANIMAL ASCITES]&[BOVINE SERUM
ALBUMIN]-POTENTIALLY INFECTIOUS MATL IF SKIN IS PENETRATED AND/OR
MUC MEMB ARE EXPOSED. [GLYCEROL]-EYE IRRIT. SKIN IRRIT. [SURFACTANT
TWEEN 20]-DETERGENT THAT CAN BE AN EYE IRRIT. [MISC INORGANIC
SALTS]-MAY CAUSE TEMP EYE, SKIN & UPPER RES P TRACT IRRITATION.
[SUCCINIC ACID (BUTANEDIOIC ACID)]-WEAK ACID. (CONT'D IN
'TRANSPORT' BLOCK)